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Pregnancy May be an Excellent Time to Cure Hepatitis C, says Magee Researcher


A small phase I clinical trial at Magee-Womens Research Institute suggests that, contrary to traditional belief, pregnancy could be an excellent time to diagnose and cure Hepatitis C infection, a lifelong infection that attacks the liver. The results of the trial indicate that an antiviral drug cocktail (ledipasvir and sogfosbuvir) resulted in 100% Hepatitis C cure rate among nine pregnant volunteers, and none of their infants contracted the virus. There were no apparent adverse effects from the drug cocktail on the infants. Catherine Chappell, MD, MS, assistant professor of obstetrics, gynecology and reproductive science at the University of Pittsburgh School of Medicine, is the lead author of the study. “During pregnancy, many women are motivated to make positive changes and get a fresh start for their health and that of their children. This could be a window of opportunity.”

Dr. Chappell says that more study is needed to test the safety and efficacy of these drugs and she is joining a multicenter phase II clinical trial to meet that goal.

Most of the nine study participants are recovering intravenous drug users who received comprehensive treatment through the Pregnancy and Womens Recovery Center at Magee Womens Hospital.



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